Quinolines and derivatives
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Filtered Search Results
Apexbio Technology LLC RO4929097(Synonyms: RO-4929097, RO 4929097, Gamma-Secretase Inhibitor RO4929097, RO4929097 γ-secretase inhibitor), 200mg, CAS: 847925-91-1.
RO4929097 (CAS 847925-91-1) is a potent selective small-molecule inhibitor of -secretase an essential protease in the Notch signaling pathway It inhibits -secretase with high specificity (IC50 4 nM EC50 5 nM) showing minimal inhibitory activity against closely related proteases and over 100-fold selectivity versus a broad spectrum of other proteases By preventing Notch receptor cleavage and subsequent signaling activation RO4929097 suppresses proliferation and tumorigenesis across various tumor models including melanoma breast colorectal pancreatic and lung cancers Clinical studies have assessed RO4929097 alone or combined with other anticancer agents for advanced solid tumors
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Apexbio Technology LLC Rosiglitazone(Synonyms: Avandia, BRL-49653, Rosiglitazone Maleate, Rosiglitazone Base, BRL49653C, RGZ, Rosiglizole), 200mg, CAS: 122320-73-4.
Rosiglitazone (CAS 122320-73-4) is a synthetic thiazolidinedione (TZD) that functions as an agonist of peroxisome proliferator-activated receptor gamma (PPAR ) a nuclear receptor highly expressed in adipose tissues Upon ligand binding PPAR forms heterodimers with retinoid X receptors promoting transcriptional activation of genes regulating adipogenesis glucose uptake lipid metabolism and insulin sensitivity Through modulating fatty acid storage in adipose tissue and secretion of adipokines rosiglitazone significantly enhances insulin sensitivity making it extensively utilized in metabolic and diabetes research particularly type II diabetes studies
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Apexbio Technology LLC Cytarabine(Synonyms: Ara-C, Cytosine arabinoside, Arabinosylcytosine, Cytosar-U, Cytosar, Depocyt), 200mg, CAS: 147-94-4.
Cytarabine (CAS 147-94-4) also known as AraC is a nucleoside analog structurally related to deoxycytidine It acts primarily by incorporation into DNA subsequently hindering DNA synthesis via inhibition of DNA and RNA polymerases AraC requires phosphorylation by deoxycytidine kinase (dCK) to its active monophosphate metabolite Reduced dCK activity or expression of alternatively spliced inactive dCK isoforms has been linked to resistance in leukemic cell lines Additionally cytarabine induces apoptosis and inhibits cell proliferation involving p53 stabilization independent of transcriptional elevation as demonstrated in rat trophoblast cells Clinically cytarabine remains extensively studied in leukemia models and cellular apoptosis pathways
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Apexbio Technology LLC Fingolimod (FTY720) 162359-56-0 200mg
Fingolimod (FTY720 CAS 162359-56-0) is an orally administered sphingosine-1-phosphate (S1P) receptor agonist structurally analogous to natural sphingosine Originally derived from fungal metabolites and initially investigated in organ transplantation fingolimod interacts potently with receptors S1P1 S1P3 S1P4 and S1P5 (EC50 values approximately 0 3 3 1 nM) Its agonism promotes receptor internalization suppressing lymphocyte migration from lymph nodes into the circulation and central nervous system (CNS) Thus fingolimod is studied primarily for autoimmune disorders especially multiple sclerosis due to its effects on lymphocyte trafficking and CNS infiltration
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Apexbio Technology LLC MK-5108 (VX-689) 1010085-13-8 200mg
MK-5108 (VX-689 CAS 1010085-13-8) is a selective inhibitor targeting Aurora A kinase (AAK) functioning through competitive interaction with its ATP-binding pocket It exhibits sub-nanomolar inhibition of Aurora A kinase (IC50 0 064 nM) and displays additional inhibitory activity against Aurora B and Aurora C kinases (IC50 14 nM and IC50 12 nM respectively) MK-5108 has been extensively studied in cancer research contexts demonstrating antiproliferative activity across various tumor types including breast cervical colorectal ovarian and pancreatic cancers
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eMolecules 5467-57-2 | 2-Chloroquinoline-4-carboxylic acid | Combi-Blocks | MFCD00023940 | 207.610 | C10H6ClNO2 | 96.000 | OC(=O)c1cc(Cl)nc2ccccc12 | 5g | 117564682
2-Chloroquinoline-4-carboxylic acid | Combi-Blocks | 5467-57-2 | MFCD00023940 | 207.610 | C10H6ClNO2 | 96.000 | OC(=O)c1cc(Cl)nc2ccccc12 | 5g | 117564682
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Medchemexpress LLC Chelerythrine chloride | 3895-92-9 | 99.1% | 25MG
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Chelerythrine chloride | 3895-92-9 | 99.1% | 25MG
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Medchemexpress LLC ETHIDIUM HOMODIMER 500 ug
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ETHIDIUM HOMODIMER 500UG
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Medchemexpress LLC DIHYDREXIDINE HYDRO 1 mg
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DIHYDREXIDINE HYDRO 1MG
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Medchemexpress LLC Chelerythrine chloride | 3895-92-9 | >98.0% | 5MG
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Chelerythrine chloride | 3895-92-9 | >98.0% | 5MG
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Selleck Chemical LLC Propidium Iodide
Propidium iodide (PI) is a red-fluorescent DNA stain which penetrates only damaged cellular membranes Propidium iodide (PI) is described for use in the determination of cell viability in cell suspension
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Medchemexpress LLC CPPD-Q 5 mg
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CPPD-Q 5MG
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Medchemexpress LLC 8PPD-Q | 99.9% | 326.43 | 25 MG
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8PPD-Q, a para-phenylenediamine quinone, is a rubber antioxidant. It exhibits superior antioxidant and anti-ozone activities but is toxic to aquatic species, particularly salmonids. 8PPD-Q can be utilized for environmental pollution research.
- Rubber antioxidant
- Superior antioxidant activity
- Anti-ozone activity
- Can be used for environmental pollution research
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Selleck Chemical LLC Tertiapin-Q-E0016-25MG
Tertiapin-Q (TPNQ) is a derivative of tertiapin and inhibits BK-type K channels in a use- and concentration-dependent manner Tertiapin-Q also binds to ROMK1 (Kir1 1) and GIRK1/4 (Kir3 1/3 4) channels with Ki values of 1 3 nM and 13 3 nM respectively
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Selleck Chemical LLC Q-VD-Oph
Q-VD-Oph (Quinoline-Val-Asp-Difluorophenoxymethylketone) is a potent pan-caspase inhibitor with IC50 ranged from 25 to 400 nM for caspases 1 3 8 and 9 Q-VD-OPh can inhibits HIV infection
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